Complete response of metastatic renal cancer with dendritic cell vaccine

Effects of Dendritic Cell Vaccine Activated with Components of Lieshmania Major on Tumor Specific Response

Background: Dendritic cells (DCs) contribute essentially to the outset and course of immune responses. So in patients with malignancy, there have been considerable interests in use of these cells in different interventions. Objective: To evaluate the impact of Leishmania major’s components on DC maturation and their use as a therapeutic agent against t...

Complete cerebral response with sunitinib for metastatic renal cell carcinoma.

Renal cell carcinoma (RCC) is a relatively rare cancer, representing 2–3% of the neoplasms in the adult population. Metastasis is in 30% of cases synchronous to the diagnosis of RCC. The most frequent common sites of metastasis include lung, liver, bone, brain and adrenal gland [1]. Brain metastasis from RCC is responsible for significant mortality [2]. RCC is characterized by the inactivation ...

Complete Radiologic Response in Metastatic Castration-Resistant Prostate Cancer Treated with Cabazitaxel

Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy.

PURPOSE Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies and nephrectomy, isolated or combined with systemic chemotherapy typically has limited or no effectiveness. We report our initial results in patients treated with the association of molecular targeted therapy, nephrectomy, and hybrid dendritic-tumor cell (DC) vaccine. MATERIALS AND METHODS Two ma...

Metastatic renal cell cancer

Targeted therapy is the treatment of choice in patients with metastatic renal cell cancer (mRCC) at most institutions although a combination of cytokine therapy and targeted therapy still is being investigated. Morphological size-based criteria (RECIST) has failed in monitoring the effect of targeted therapy in patients with mRCC, as successful therapy often does not result in a decrease in tum...